Antiviral Drugs

Indication:

Sofosbuvir With Velpatasvir is a two-drug combination for the treatment of hepatitis C. It is administered as a single daily pill containing the viral NS5A inhibitor velpatasvir and sofosbuvir, a nucleotide inhibitor of the viral RNA polymerase. It is the first treatment, that works for all genotypic, and is taken entirely by mouth. A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection.

Mechanism of action:

Sofosbuvir With Velpatasvir is an oral fixed-dose combination of sofosbuvir, a nucleotide analog NS5B polymerase inhibitor and velapatasvir, an NS5A replication complex inhibitor. Sofosbuvir is approved for the treatment of genotype 1, 2, 3 and 4 HCV infection with different regimens and durations dependent on the HCV genotype. Velpatasvir (formerly GS-5816) is a novel NS5A inhibitor that has potent invitro anti-HCV activity across all genotypes at the picomolar level. The combination of sofosbuvir-velpatasvir is the first once-daily single-tablet regimen with pangenotypic activity.

Dosage and Administration:

Sofosbuvir With Velpatasvir is available as a coformulated, once-daily single-pill combination of sofosbuvir 400 mg and velpatasvir 100 mg. The recommended dose is one tablet once daily, taken with or without food.

• Renal Impairment: For patients with mild to moderate renal impairment, no dosage adjustment of sofosbuvir-velpatasvir is recommended. There are insufficient data regarding the safety and efficacy of sofosbuvir-velpatasvir in patients with severe renal impairment (eGFR less than 30 ml/min/1.73m2) or end-stage renal disease requiring hemodialysis. Accordingly, no dosage recommendation has been given for patients with severe renal impairment or end-stage renal disease requiring dialysis.
• Hepatic Impairment: For patients with mild, moderate, or severe hepatic impairment (Child-Pugh Class A, B, or C), no dosage adjustment for sofosbuvir-velpatasvir is recommended. For patients with decompensated cirrhosis who are receiving sofosbuvir-velpatasvir and ribavirin, clinical and laboratory monitoring is recommended.

Precaution:

Risk of Serious Symptomatic Bradycardia When Sofosbuvir Is Coadministered with Amiodarone and Another HCV Direct Acting Antiviral: Amiodarone is not recommended for use with Sofosbuvir With Velpatasvir due to the risk of symptomatic bradycardia, particularly in patients also taking beta blockers or with underlying cardiac comorbidities and/or with advanced liver disease. In patients without alternative, viable treatment options, cardiac monitoring is recommended. Patients should seek immediate medical evaluation if they develop signs or symptoms of bradycardia.

Risk of Reduced Therapeutic Effect Due to Concomitant Use of Sofosbuvir With Velpatasvir with P-gp Inducers and/or Moderate to Potent Inducers of CYP2B6, CYP2C8 or CYP3A4: Rifampin, St. Johns wort, and carbamazepine are not recommended for use with Sofosbuvir With Velpatasvir as they may significantly decrease sofosbuvir and/or velpatasvir plasma concentrations.

The benefits of therapy can be presented in this way

• Safety and high efficiency;
• High rates of absorption;
• Minimal, delayed resistance;
• Persistent remission.

Entekor 1 mg suppresses the replica of the HBV virus in all three stages, penetrates into the cells affected by the virus, and prevents the splitting of the protein of the viral particle, thus affecting the process of reproduction of the viral RNA.

The recommended dose is 1 tablet per day. Take inside on an empty stomach.

In the presence of pathological processes of the liver or kidneys of various origin, the dosage is selected strictly individually.

The use of the drug may cause adverse reactions in the body, this is:

• dizziness;

• state of lack of sleep;
• general weakness and fatigue;
• pain in the abdominal cavity;
• allergic reactions;
• muscular asthenia;
• labored breathing.

Entekor (Entecavir 1mg refers to new drugs from the group of nucleoside analogues for the treatment of chronic HBV infection. It is a carboxylic analogue of 2'-deoxyguanosine, rapidly transforming into a cell in an active form, suppressing the replication of HBV in all its three stages - initiation, elongation, termination. 

Conducted studies of the efficacy of Entecavir in the treatment of patients with chronic hepatitis B showed good tolerability, a high safety profile, a higher efficacy than Lamivudine, and a lack of resistance after 2 years of administration in patients previously untreated with nucleoside analogues. The efficacy of the drug for prescribing patients resistant to Lamivudine was also demonstrated. In all of these cases, Entecavir can be considered the first-line therapy for HBV infection.

Note:
For oral use

• Delivery Time: 7 to 14 Days

Ivermectin is an anti-parasite medication used to treat parasitic diseases.

Ivermectin is an FDA approved drug for use in humans to treat a variety of parasitic infections including parasitic worms, hookworm and whipworm. It may also be used as an effective treatment for a wide range of other conditions and as a treatment of onchocerciasis, intestinal strongyloidiasis and onchocerciasis or river blindness.

The antiviral activity of Ivermectin has been shown against a wide range of RNA and DNA viruses, for example, dengue, Zika, yellow fever, and others.

Favipiravir is an antiviral medicine. It stops the SARS-CoV-2 virus from multiplying. By doing so, it decreases viral load in the body, restricts the spread of infection and helps in speeding up the recovery process.

Dosage:

• As directed by physician

Storage:

• Store at a temperature not exceeding 30 DegreeC

Note:

• Keep out of reach of children

Tenof 300 mg (Tenofovir disoproxil fumarate) acts by hindering the multiplication (replication) of the virus in human cells.Tenofovir disoproxil fumarate is not used to cure HIV-1 infection but only to cut the HIV tool on the body. This allows to prevent some problems associated with HIV-1 infection and improve the life span.

Tenof tablet is administered orally in patients (adults and children over 2 years of age) weighing at least 35 kgs.

For both HIV-1 and HBV infections, the dosage of 300 mg tablet remains the same.

Other Details:

• The active substance is tenofovir, while tenofovir disoproxil is a prodrug that is used because of its better absorption in the gut
• The drug is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system
• It is marketed by Sciences under the trade name

Dosage:

• As directed by physician

Storage:

• Store in a cool and dry place

Note:

• Keep the container tightly closed
• Keep out of reach of children

Fabiflu pill is an antiviral remedy. it's miles used for the remedy of slight to mild coronavirus disease (COVID-19) in adults. It stops the virus from multiplying and therefore, decreases the viral load inside the frame.
Take Fabiflu pill simplest as in line with the dose and period recommended by way of your doctor. Do not self-medicate. The most commonplace facet results of this medication consist of the extended uric acid ranges in blood, diarrhea, decreased white blood cell count (neutrophils), and increased liver enzymes. If any of those aspect effects trouble you, seek advice from your doctor.To ensure it's far secure for you, you must allow your physician understand if you have severe kidney or liver disorder before taking this medicine. Fabiflu pill isn't encouraged for women who're pregnant, suspected to be pregnant or breastfeeding, as it is able to cause harmful effects to the developing infant. additionally, tell your health practitioner if you have a records of hypersensitive reaction to this drug, have abnormalities in uric acid metabolism, or have gout.

Dosage:

• As directed by physician

Storage:

• Store below 30 Degree C
• Protect from moisture

Note:

• Keep the container tightly closed
• Keep out of reach of children
• For India only

Valgan 450 mg tablet is used for the treatment of cytomegalovirus (CMV) infection of retina (retinitis) in adult patients with acquired immunodeficiency syndrome (AIDS). It is also used for the prevention of CMV infection in patients who have received an organ transplant from a CMV-infected donor.

How it works:
Valgan 450 mg tablet is an antiviral drug which belongs to class of medications called purine analogues. After oral intake, Valgan 450 mg tablet gets converted into ganciclovir by liver and intestinal enzymes, which then prevents the growth and spread of cytomegalovirus.

Common side effects:
Night sweats, Pain, Abdominal pain, Abnormal thoughts, Anxiety, Back pain, Blood infection, Bone pain, Stiffness, Chest pain, Chills, Confusion, Constipation, Convulsion, Cough, Decrease in body weight, Depression, Disorientation (alteration of mental status), Dizziness, Altered taste, Difficulty in swallowing, Ear pain, Decreased red blood cell count, Eye pain, Fatigue, Fever, Fungal infection of mouth, Headache, Increased creatinine level in blood, Indigestion, Insomnia, Liver enzyme increased, Loss of appetite, Feeling of discomfort, Muscle cramp, Muscle pain, Nausea, Renal impairment, Retinal detachment, Skin inflammation, Itching, Skin redness, Swelling, Urinary tract infection, Vitreous humour (part of eye) floaters, Vomiting, Weakness, Abnormal sensation in skin

How it works:
Cymgal 450 mg tablet prevents the multiplication of the virus in human cells. Thus stops the virus from producing new viruses.

Common side effects:
Impaired concentration, Rash, Reduced blood platelets, Joint pain, Stiffness, Headache, Dizziness, Back pain, Convulsion, Abnormal sensation in skin, Sepsis, Vitreous humour (part of eye) floaters, Photosensitivity, Punctate keratitis, Muscle pain, Cellulitis, Insomnia, Decreased red blood cell count, Eye pain, Pain, Vomiting, Weakness, Skin flakes, Inflammation, Nausea, Abdominal pain, Dermatitis, Irritability, Indigestion, Difficulty in swallowing, Skin inflammation, Loss of appetite, Numbness, Decreased white blood cell count, Paresthesia (tingling or pricking sensation), Hair loss, Fatigue, Anxiety, Fever, Increased liver enzymes, Swelling, Anemia, Abnormal thoughts, Disorientation (alteration of mental status), Itching, Chills, Dry skin, Renal impairment, Urinary tract infection, Muscle cramp, Diarrhoea, Depression, Skin redness, Rigors, Decreased appetite, Burning sensation, Feeling of discomfort, Cough, Weight loss, Confusion, Altered taste, Blood infection, Chest pain, Decrease in body weight, Ear pain, Decreased white blood cell count (neutrophils), Bone pain, Neuropathy, Constipation, Increased creatinine level in blood, Night sweats, Fungal infection of mouth, Retinal detachment, Breathing difficulty

How it works?
Entavir 0.5 mg tablet is an antiviral drug and belongs to class of drugs called synthetic nucleoside analogues. It works by blocking the DNA synthesis in hepatitis B virus, a process essential for the virus to grow and multiply. Entavir 0.5 mg tablet thus stops the virus from spreading in the body. It does not prevent spread of HBV infections to other people.

Common side effects:
Nausea, Rash, Allergic reaction, Dizziness, Hair loss, Headache, Indigestion, Vomiting, Fatigue, Worsening of hepatitis b (viral infection of liver), Lactic acidosis

WHAT IS NATCLOVIR 250 MG CAPSULES ?

Natclovir is an antiviral agent. It works by blocking reproduction of the CMV virus. It helps control CMV retinitis and decrease the risk of blindness.

WHAT IS THE USE OF NATCLOVIR 250 MG CAPSULES ?

It is used to prevent disease caused by a virus called cytomegalovirus (CMV) in people who have received organ or bone marrow transplants. CMV disease can lead to serious infections in the body, including an infection in the eye, called CMV retinitis, that can cause blindness. Ganciclovir 250 mg is also used to treat people with weakened immune systems (including people with AIDS) who have CMV retinitis.

WHAT ARE THE POSSIBLE SIDE-EFFECTS OF NATCLOVIR 250 MG CAPSULES ?

Diarrhea, upset stomach, dizziness, drowsiness, unsteadiness, shaking (tremors), or pain/redness/irritation at the injection site may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Tell your doctor right away if any of these unlikely but serious side effects occur: mental/mood changes (such as confusion, hallucinations), signs of kidney problems (such as change in the amount of urine), seizures.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.

• Delivery Time: 5 to 10 days